DOK2

Docking protein 2 is a protein that in humans is encoded by the DOK2 gene.^[5][6][7]

DOK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D9W, 2DLW
Identifiers
Aliases	DOK2, p56DOK, p56dok-2, docking protein 2
External IDs	OMIM: 604997; MGI: 1332623; HomoloGene: 2957; GeneCards: DOK2; OMA:DOK2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.3 Start 21,908,873 bp[1] End 21,913,690 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D2|14 36.71 cM Start 70,766,036 bp[2] End 70,778,495 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood spleen lymph node appendix upper lobe of left lung testicle lower lobe of lung right lung Top expressed in granulocyte thymus tibiofemoral joint blood spleen morula embryo embryo lymph node fetal liver hematopoietic progenitor cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transmembrane receptor protein tyrosine kinase adaptor activity Cellular component cytosol Biological process cell surface receptor signaling pathway Ras protein signal transduction leukocyte migration signal transduction transmembrane receptor protein tyrosine kinase signaling pathway axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9046 13449 Ensembl ENSG00000147443 ENSMUSG00000022102 UniProt O60496 O70469 RefSeq (mRNA) NM_003974 NM_201349 NM_001317800 NM_001401272 NM_010071 RefSeq (protein) NP_001304729 NP_003965 NP_958728 NP_034201 NP_001388209 NP_001388210 Location (UCSC) Chr 8: 21.91 – 21.91 Mb Chr 14: 70.77 – 70.78 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.^[7]

Interactions

DOK2 has been shown to interact with INPP5D^[8] and TEK tyrosine kinase.^[9][10]