CD24

Signal transducer CD24 also known as cluster of differentiation 24 or heat stable antigen CD24 (HSA) is a protein that in humans is encoded by the CD24 gene.^[5] CD24 is a cell adhesion molecule.

CD24
Identifiers
Aliases	CD24, CD24A, CD24 molecule
External IDs	OMIM: 600074; MGI: 88323; GeneCards: CD24; OMA:CD24 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q21 Start 106,969,831 bp[1] End 106,975,627 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 B2|10 23.01 cM Start 43,454,280 bp[2] End 43,460,261 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla bronchial epithelial cell mucosa of colon mucosa of sigmoid colon oral cavity parotid gland gingival epithelium epithelium of nasopharynx mucosa of ileum pancreatic epithelial cell Top expressed in fetal liver hematopoietic progenitor cell crypt of lieberkuhn of small intestine superior cervical ganglion epithelium of stomach human fetus medial ganglionic eminence epithelium of lens parotid gland tibiofemoral joint blood More reference expression data BioGPS n/a
Gene ontology Molecular function protein tyrosine kinase activator activity signal transducer activity protein binding protein kinase binding Cellular component membrane plasma membrane cell surface anchored component of external side of plasma membrane membrane raft anchored component of membrane intracellular anatomical structure Biological process response to hypoxia regulation of MAPK cascade positive regulation of MAP kinase activity regulation of cytokine-mediated signaling pathway positive regulation of cytosolic calcium ion concentration chemokine receptor transport out of membrane raft T cell costimulation regulation of phosphorylation Wnt signaling pathway negative regulation of transforming growth factor beta3 production cell activation immune response-regulating cell surface receptor signaling pathway response to estrogen respiratory burst intrinsic apoptotic signaling pathway glomerular parietal epithelial cell differentiation cell adhesion glomerular visceral epithelial cell differentiation cholesterol homeostasis regulation of epithelial cell differentiation response to molecule of bacterial origin cell migration B cell receptor transport into membrane raft positive regulation of nephron tubule epithelial cell differentiation positive regulation of activated T cell proliferation positive regulation of protein tyrosine kinase activity cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 100133941 12484 Ensembl ENSG00000272398 ENSMUSG00000047139 UniProt P25063 P24807 RefSeq (mRNA) NM_001291737 NM_001291738 NM_001291739 NM_013230 NM_001359084 NM_009846 RefSeq (protein) NP_001278666 NP_001278667 NP_001278668 NP_037362 NP_001346013 NP_033976 Location (UCSC) Chr 6: 106.97 – 106.98 Mb Chr 10: 43.45 – 43.46 Mb PubMed search [3] [4]
Wikidata
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Function

CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils^[6] and neutrophil precursors from the myelocyte stage onwards. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. The protein also contributes to a wide range of downstream signaling networks and is crucial for neural development.^[7] Cross-linking of CD24 on the surface of neutrophils induces apoptosis,^[8] and this appears to be defective in sepsis.^[8] CD24 gene is found on chromosome 6 (6q21) An alignment of this gene's sequence finds genomic locations with similarity on chromosomes 1p36, 3p26, 15q21.3, 20q11.2 and Yq11.222. Whether transcription, and corresponding translation, occurs at each of these other genomic locations needs to be experimentally determined.^{[citation needed]}

Researchers have identified CD24 as a novel cell surface marker that flags anastasis in melanoma cells, a process where cells that have initiated apoptosis can recover and survive.^[9] This discovery highlights CD24’s role in marking apoptotic subpopulations that exhibit metabolic activity and proliferative capacities, contributing to melanoma’s resilience and potential metastasis.