CD3D

T-cell surface glycoprotein CD3 delta chain is a protein that in humans is encoded by the CD3D gene.^[5]

CD3D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XIW
Identifiers
Aliases	CD3D, CD3-DELTA, IMD19, T3D, CD3d molecule, CD3 delta subunit of T-cell receptor complex, CD3DELTA
External IDs	OMIM: 186790; MGI: 88331; HomoloGene: 585; GeneCards: CD3D; OMA:CD3D - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 118,339,075 bp[1] End 118,342,705 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.2|9 24.84 cM Start 44,893,084 bp[2] End 44,898,637 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus granulocyte lymph node appendix blood spleen epithelium of nasopharynx testicle mucosa of ileum bone marrow Top expressed in thymus mesenteric lymph nodes blood spleen granulocyte subcutaneous adipose tissue pharynx right lung lobe spermatid superior surface of tongue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity protein heterodimerization activity transmembrane signaling receptor activity protein homodimerization activity Cellular component membrane cytoplasm alpha-beta T cell receptor complex integral component of membrane T cell receptor complex clathrin-coated vesicle membrane plasma membrane external side of plasma membrane Biological process positive regulation of transcription by RNA polymerase II regulation of immune response T cell receptor signaling pathway T cell differentiation positive thymic T cell selection cell surface receptor signaling pathway membrane organization protein homooligomerization adaptive immune response immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 915 12500 Ensembl ENSG00000167286 ENSMUSG00000032094 UniProt P04234 P04235 RefSeq (mRNA) NM_001040651 NM_000732 NM_013487 RefSeq (protein) NP_000723 NP_001035741 NP_038515 Location (UCSC) Chr 11: 118.34 – 118.34 Mb Chr 9: 44.89 – 44.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CD3D has been shown to interact with CD8A.^[6]

See also

• CD3 (immunology)
• Cluster of differentiation