Integrin alpha 3

Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene.^[5][6] ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.

ITGA3
Identifiers
Aliases	ITGA3, CD49C, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a, FRP-2, integrin subunit alpha 3, JEB7
External IDs	OMIM: 605025; MGI: 96602; HomoloGene: 21129; GeneCards: ITGA3; OMA:ITGA3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.33 Start 50,055,968 bp[1] End 50,090,481 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 59.01 cM Start 94,935,300 bp[2] End 94,967,627 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in metanephric glomerulus right coronary artery upper lobe of left lung Descending thoracic aorta popliteal artery tibial arteries right lung right lobe of thyroid gland ascending aorta left lobe of thyroid gland Top expressed in genital tubercle lumbar spinal ganglion decidua tail of embryo corneal stroma yolk sac crypt of lieberkuhn of small intestine right lung lobe epithelium of lens ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding protein domain specific binding laminin binding collagen binding protease binding protein heterodimerization activity integrin binding fibronectin binding protein binding Cellular component extracellular exosome synapse integral component of membrane cell projection cell periphery cell junction growth cone membrane focal adhesion cell surface receptor complex synaptic membrane perinuclear region of cytoplasm excitatory synapse integrin complex basolateral plasma membrane filopodium membrane external side of plasma membrane integrin alpha3-beta1 complex plasma membrane growth cone filopodium Biological process positive regulation of neuron projection development extracellular matrix organization lung development mesodermal cell differentiation skin development maternal process involved in female pregnancy cell-matrix adhesion negative regulation of cell projection organization positive regulation of cell-substrate adhesion heart development dendritic spine maintenance positive regulation of gene expression nephron development memory integrin-mediated signaling pathway response to gonadotropin leukocyte migration renal filtration regulation of transforming growth factor beta receptor signaling pathway regulation of Wnt signaling pathway regulation of BMP signaling pathway negative regulation of Rho protein signal transduction exploration behavior positive regulation of epithelial cell migration neuron migration cell adhesion positive regulation of protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3675 16400 Ensembl ENSG00000005884 ENSMUSG00000001507 UniProt P26006 Q62470 RefSeq (mRNA) NM_002204 NM_005501 NM_013565 NM_001306071 NM_001306162 RefSeq (protein) NP_002195 NP_001293000 NP_001293091 NP_038593 Location (UCSC) Chr 17: 50.06 – 50.09 Mb Chr 11: 94.94 – 94.97 Mb PubMed search [3] [4]
Wikidata
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ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular matrix proteins.

Alternative names

The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').^[7]

Interactions

CD49c has been shown to interact with:

• CD9^[8][9]
• FHL2,^[10]
• LGALS8,^[11] and
• TSPAN4.^[12]