TSPAN4

Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.^[5][6]

TSPAN4
Identifiers
Aliases	TSPAN4, NAG-2, NAG2, TETRASPAN, TM4SF7, TSPAN-4, tetraspanin 4
External IDs	OMIM: 602644; MGI: 1928097; HomoloGene: 2453; GeneCards: TSPAN4; OMA:TSPAN4 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 842,812 bp[1] End 867,116 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 141,055,153 bp[2] End 141,073,340 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium right lung left uterine tube right ovary canal of the cervix left ovary body of uterus subcutaneous adipose tissue upper lobe of left lung tibial nerve Top expressed in stroma of bone marrow decidua calvaria gastrula endothelial cell of lymphatic vessel internal carotid artery external carotid artery right kidney adrenal gland choroid plexus of fourth ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function antigen binding integrin binding protein binding Cellular component integral component of membrane vesicle plasma membrane integral component of plasma membrane membrane focal adhesion Biological process cell surface receptor signaling pathway protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7106 64540 Ensembl ENSG00000214063 ENSMUSG00000025511 UniProt O14817 Q9DCK3 RefSeq (mRNA) NM_001025234 NM_001025235 NM_001025236 NM_001025237 NM_001025238 NM_001025239 NM_003271 NM_001252588 NM_053082 RefSeq (protein) NP_001020405 NP_001020406 NP_001020407 NP_001020408 NP_001020409 NP_001020410 NP_003262 NP_001239517 NP_444312 NP_001390284 NP_001390285 NP_001390286 NP_001390287 Location (UCSC) Chr 11: 0.84 – 0.87 Mb Chr 7: 141.06 – 141.07 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.^[6]

Interactions

TSPAN4 has been shown to interact with CD9,^[5] ITGA6,^[5] CD29,^[5] CD49c^[5] and CD81.^[5]