CD6

CD6 (Cluster of Differentiation 6) is a human protein encoded by the CD6 gene.^[5][6]

CD6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5A2E
Identifiers
Aliases	CD6, TP120, CD6 molecule
External IDs	OMIM: 186720; MGI: 103566; HomoloGene: 4893; GeneCards: CD6; OMA:CD6 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.2 Start 60,971,680 bp[1] End 61,020,377 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 7.16 cM Start 10,766,705 bp[2] End 10,807,422 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte lymph node blood thymus appendix spleen cervix epithelium superficial temporal artery bone marrow endothelial cell Top expressed in thymus mesenteric lymph nodes blood granulocyte embryo axillary lymph node subcutaneous adipose tissue embryo spleen morula More reference expression data BioGPS n/a
Gene ontology Molecular function lipopolysaccharide binding lipoteichoic acid binding scavenger receptor activity protein binding identical protein binding Cellular component integral component of membrane membrane intrinsic component of plasma membrane plasma membrane integral component of plasma membrane T cell receptor complex extracellular region immunological synapse external side of plasma membrane Biological process positive regulation of cytokine production involved in inflammatory response heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules adaptive immune response immune system process acute inflammatory response to antigenic stimulus receptor-mediated endocytosis response to lipopolysaccharide cell adhesion positive regulation of T cell proliferation innate immune response immunological synapse formation lipopolysaccharide-mediated signaling pathway vesicle-mediated transport endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 923 12511 Ensembl ENSG00000013725 ENSMUSG00000024670 UniProt P30203 Q61003 RefSeq (mRNA) NM_001254750 NM_001254751 NM_006725 NM_001037801 NM_009852 RefSeq (protein) NP_001241679 NP_001241680 NP_006716 NP_001032890 NP_033982 Location (UCSC) Chr 11: 60.97 – 61.02 Mb Chr 19: 10.77 – 10.81 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation.^[5]

Clinical significance

Certain alleles of this gene may be associated with susceptibility to multiple sclerosis.^[7][8]

See also

• Cluster of differentiation