CD7

CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene.^[5]

CD7
Identifiers
Aliases	CD7, GP40, LEU-9, TP41, Tp40, CD7 molecule
External IDs	OMIM: 186820; MGI: 88344; HomoloGene: 4471; GeneCards: CD7; OMA:CD7 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 82,314,868 bp[1] End 82,317,608 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E2|11 84.85 cM Start 120,927,573 bp[2] End 120,930,244 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood spleen appendix lymph node thymus mucosa of transverse colon upper lobe of left lung bone marrow cells right lung Top expressed in morula zygote primary oocyte blood secondary oocyte duodenum thymus spleen jejunum intestinal villus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor activity Cellular component integral component of membrane plasma membrane membrane Biological process adaptive immune response T cell activation immune response transmembrane receptor protein tyrosine kinase signaling pathway immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 924 12516 Ensembl ENSG00000173762 ENSMUSG00000025163 UniProt P09564 P50283 RefSeq (mRNA) NM_006137 NM_009854 RefSeq (protein) NP_006128 NP_033984 Location (UCSC) Chr 17: 82.31 – 82.32 Mb Chr 11: 120.93 – 120.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.^[5]

See also

• Cluster of differentiation
• DC-7

Interactions

CD7 has been shown to interact with PIK3R1.^[6][7]

Clinical significance

CD7 can be aberrantly expressed in refractory anaemia with excess blasts (RAEB) and may confer a worse prognosis.^[8] Also, a lack of CD7 expression could insinuate mycosis fungoides (MF) or Sezary syndrome (SS).^[9]