CD98

CD98 is a glycoprotein^[1][2] that is a heterodimer composed of SLC3A2 and SLC7A5 that forms the large neutral amino acid transporter (LAT1). LAT1 is a heterodimeric membrane transport protein that preferentially transports branched-chain (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine, phenylalanine) amino acids.^[3] LAT is highly expressed in brain capillaries (which form the blood–brain barrier) relative to other tissues.^[3]

solute carrier family 3 member 2 (activators of dibasic and neutral amino acid transport)
Identifiers
Symbol	SLC3A2
Alt. symbols	MDU1, 4T2HC, 4F2, NACAE, CD98
NCBI gene	6520
HGNC	11026
OMIM	158070
RefSeq	NM_001013251
UniProt	P08195
Other data
Locus	Chr. 11 q12-q22
Search for Structures Swiss-model Domains InterPro

solute carrier family 7 member 5 (cationic amino acid transporter, y+ system)
Identifiers
Symbol	SLC7A5
Alt. symbols	LAT1, E16, D16S469E, MPE16, CD98
NCBI gene	8140
HGNC	11063
OMIM	600182
RefSeq	NM_003486
UniProt	Q01650
Other data
Locus	Chr. 16 q24.3
Search for Structures Swiss-model Domains InterPro

A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:

• 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene ^[4]
• CD98 light subunit protein encoded by the SLC7A5 gene^[5]

See also

• Cluster of differentiation
• Transmembrane protein
• Transport protein
• Solute carrier family