4F2 cell-surface antigen heavy chain

4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 (solute carrier family 3 member 2) gene.^[5][6]

SLC3A2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DH2, 2DH3
Identifiers
Aliases	SLC3A2, 4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE, solute carrier family 3 member 2
External IDs	OMIM: 158070; MGI: 96955; HomoloGene: 1795; GeneCards: SLC3A2; OMA:SLC3A2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.3 Start 62,856,004 bp[1] End 62,888,880 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 5.44 cM Start 8,684,246 bp[2] End 8,700,733 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans ventricular zone stromal cell of endometrium right lobe of thyroid gland left lobe of thyroid gland ganglionic eminence upper lobe of left lung skin of abdomen canal of the cervix skin of leg Top expressed in epithelium of lens choroid plexus of fourth ventricle submandibular gland parotid gland calvaria spermatocyte stroma of bone marrow right kidney neural layer of retina lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium:sodium antiporter activity neutral amino acid transmembrane transporter activity catalytic activity protein binding double-stranded RNA binding RNA binding cadherin binding Cellular component integral component of membrane membrane melanosome plasma membrane cell surface apical plasma membrane extracellular exosome nucleus cytosol Biological process response to exogenous dsRNA cell growth amino acid transport leukocyte migration calcium ion transport tryptophan transport sodium ion transmembrane transport L-alpha-amino acid transmembrane transport transport carbohydrate metabolic process L-leucine import across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6520 17254 Ensembl ENSG00000168003 ENSMUSG00000010095 UniProt P08195 P10852 RefSeq (mRNA) NM_001012661 NM_001012662 NM_001012663 NM_001012664 NM_001013251 NM_002394 NM_001161413 NM_008577 RefSeq (protein) NP_001012680 NP_001012682 NP_001013269 NP_002385 NP_001154885 NP_032603 Location (UCSC) Chr 11: 62.86 – 62.89 Mb Chr 19: 8.68 – 8.7 Mb PubMed search [3] [4]
Wikidata
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SLC3A2 comprises the heavy subunit of the large neutral amino acid transporter (LAT1) that is also known as CD98 (cluster of differentiation 98).^[7][8]

Function

SLC3A2 is a member of the solute carrier family and encodes a cell surface, transmembrane protein with an alpha-amylase domain. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. It associates with integrins and mediates integrin-dependent signaling related to normal cell growth and tumorigenesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[6]

LAT1 is a heterodimeric membrane transport protein that preferentially transports neutral branched (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine, phenylalanine) amino acids.^[9] LAT is highly expressed in brain capillaries (which form the blood brain barrier) relative to other tissues.^[9]

A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:

• 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene (this gene)^[10]
• CD98 light subunit protein encoded by the SLC7A5 gene^[11]

Interactions

SLC3A2 has been shown to interact with SLC7A7.^[12]

Additionally, SLC3A2 is a constituent member of the system xc- cystine/glutamate antiporter, complexing with SLC7A11.

See also

• Heterodimeric amino acid transporter