CDC14B

Dual specificity protein phosphatase CDC14B is an enzyme that in humans is encoded by the CDC14B gene.^[5][6]

CDC14B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OHC, 1OHD, 1OHE
Identifiers
Aliases	CDC14B, CDC14B3, Cdc14B1, Cdc14B2, hcell division cycle 14B
External IDs	OMIM: 603505; MGI: 2441808; HomoloGene: 104197; GeneCards: CDC14B; OMA:CDC14B - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.32-q22.33 Start 96,490,241 bp[1] End 96,619,843 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B3 Start 64,189,268 bp[2] End 64,275,290 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum tendon of biceps brachii internal globus pallidus optic nerve retinal pigment epithelium C1 segment gonad inferior ganglion of vagus nerve bronchial epithelial cell seminal vesicula Top expressed in hand Epithelium of choroid plexus spermatid primitive streak gastrula maxillary prominence left lobe of liver mandibular prominence tail of embryo atrium More reference expression data BioGPS n/a
Gene ontology Molecular function protein tyrosine phosphatase activity phosphoprotein phosphatase activity hydrolase activity protein tyrosine/serine/threonine phosphatase activity phosphatase activity protein binding protein serine/threonine phosphatase activity Cellular component nucleus nucleolus cytoplasm nucleoplasm spindle pole centrosome mitotic spindle Biological process DNA repair cellular response to DNA damage stimulus dephosphorylation protein dephosphorylation peptidyl-tyrosine dephosphorylation positive regulation of ubiquitin protein ligase activity regulation of exit from mitosis mitotic spindle midzone assembly cilium assembly mitotic G2 DNA damage checkpoint signaling microtubule cytoskeleton organization mitotic cell cycle positive regulation of cytokinesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8555 218294 Ensembl ENSG00000081377 ENSMUSG00000033102 UniProt O60729 Q6PFY9 RefSeq (mRNA) NM_001077181 NM_003671 NM_033331 NM_033332 NM_001351567 NM_001351568 NM_001351569 NM_001351570 NM_001122989 NM_172587 RefSeq (protein) NP_001070649 NP_003662 NP_201588 NP_001338496 NP_001338497 NP_001338498 NP_001338499 NP_001116461 NP_766175 Location (UCSC) Chr 9: 96.49 – 96.62 Mb Chr 13: 64.19 – 64.28 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. Specifically, it is thought to fulfil this role by bundling and stabilising microtubules. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in 3 transcript variants encoding distinct isoforms.^[6]

Interactions and Functions

CDC14B has been shown to interact with p53, potentially de-phosphorylate p53 at Serine 315 and thereby stabilize p53.^[7] S315-phosphorylated p53, in contrast to other p53 phosphorylation, was shown to facilitate p53 degradation.^[8] At the patho-physiological level, mice with CDC14B deletion were shown to exhibit early-onset ageing phenotypes. ^[9]