CDC26

Cell division cycle 26 is a protein that in humans is encoded by the CDC26 gene.^[5]

CDC26
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HYM, 4UI9, 5A31, 5G05, 5G04,%%s4UI9, 5A31
Identifiers
Aliases	CDC26, ANAPC12, APC12, C9orf17, cell division cycle 26
External IDs	OMIM: 614533; MGI: 1913690; HomoloGene: 16410; GeneCards: CDC26; OMA:CDC26 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q32 Start 113,255,835 bp[1] End 113,275,572 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B3 Start 62,301,891 bp[2] End 62,326,879 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon mucosa of transverse colon monocyte islet of Langerhans granulocyte apex of heart lymph node left ventricle rectum right lung Top expressed in ventricular zone medial ganglionic eminence yolk sac abdominal wall embryo endocardial cushion maxillary prominence mandibular prominence embryo dermis More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytosol anaphase-promoting complex nucleus nucleoplasm Biological process regulation of mitotic metaphase/anaphase transition cell cycle anaphase-promoting complex-dependent catabolic process protein ubiquitination protein K11-linked ubiquitination cell division regulation of mitotic cell cycle phase transition ubiquitin-dependent protein catabolic process regulation of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 246184 66440 Ensembl ENSG00000176386 ENSMUSG00000066149 UniProt Q8NHZ8 Q99JP4 RefSeq (mRNA) NM_139286 NM_139291 NM_001368241 RefSeq (protein) NP_644815 NP_644815.1 NP_647452 NP_001355170 Location (UCSC) Chr 9: 113.26 – 113.28 Mb Chr 4: 62.3 – 62.33 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008].

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Anaphase-promoting complex subunit CDC26