CDC42EP1

Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene.^[5][6][7]

CDC42EP1
Identifiers
Aliases	CDC42EP1, BORG5, CEP1, MSE55, CDC42 effector protein 1
External IDs	OMIM: 606084; MGI: 1929763; HomoloGene: 5128; GeneCards: CDC42EP1; OMA:CDC42EP1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 37,560,480 bp[1] End 37,569,405 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 78,726,824 bp[2] End 78,735,097 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas body of stomach C1 segment minor salivary glands right coronary artery left adrenal cortex left uterine tube right adrenal gland ascending aorta ectocervix Top expressed in epithelium of stomach left lung left lung lobe right lung lacrimal gland pyloric antrum white adipose tissue right lung lobe subcutaneous adipose tissue interventricular septum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity cadherin binding involved in cell-cell adhesion Cellular component cytoskeleton membrane endomembrane system focal adhesion cytoplasm plasma membrane Biological process positive regulation of pseudopodium assembly positive regulation of actin filament polymerization Rho protein signal transduction regulation of cell shape positive regulation of GTPase activity cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11135 104445 Ensembl ENSG00000128283 ENSMUSG00000049521 UniProt Q00587 Q91W92 RefSeq (mRNA) NM_152243 NM_027219 RefSeq (protein) NP_689449 NP_081495 Location (UCSC) Chr 22: 37.56 – 37.57 Mb Chr 15: 78.73 – 78.74 Mb PubMed search [3] [4]
Wikidata
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CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. The encoded protein, which is secreted, is primarily found in bone marrow. Two transcript variants encoding different isoforms have been found for this gene.^[7]