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CDC42EP2

Protein-coding gene in humans From Wikipedia, the free encyclopedia

CDC42EP2
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Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene.[5][6][7]

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Function

CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. Coexpression of this protein with dominant negative mutant CDC42 protein in fibroblast was found to induce pseudopodia formation, which suggested a role of this protein in actin filament assembly and cell shape control.[7]

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Interactions

CDC42EP2 has been shown to interact with CDC42[5][6] and RHOQ.[5]

References

Further reading

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