CDC42EP2

Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene.^[5][6][7]

CDC42EP2
Identifiers
Aliases	CDC42EP2, BORG1, CEP2, CDC42 effector protein 2
External IDs	OMIM: 606132; MGI: 1929744; HomoloGene: 4933; GeneCards: CDC42EP2; OMA:CDC42EP2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,314,866 bp[1] End 65,322,417 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 4.34 cM Start 5,965,664 bp[2] End 5,974,844 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart gastric mucosa blood C1 segment stromal cell of endometrium subcutaneous adipose tissue left uterine tube gallbladder upper lobe of left lung left ventricle Top expressed in ankle dermis soleus muscle secondary oocyte granulocyte sternocleidomastoid muscle interventricular septum temporal muscle knee joint primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity opioid peptide activity Cellular component cytoplasm microtubule cytoskeleton plasma membrane membrane endomembrane system cytoskeleton cytosol phagocytic vesicle Biological process positive regulation of pseudopodium assembly positive regulation of actin filament polymerization positive regulation of protein-containing complex assembly actin cytoskeleton organization Rho protein signal transduction actin filament organization regulation of cell shape positive regulation of GTPase activity regulation of signaling receptor activity cellular response to interferon-gamma Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10435 104252 Ensembl ENSG00000149798 ENSMUSG00000045664 UniProt O14613 Q8JZX9 RefSeq (mRNA) NM_006779 NM_026772 RefSeq (protein) NP_006770 NP_081048 Location (UCSC) Chr 11: 65.31 – 65.32 Mb Chr 19: 5.97 – 5.97 Mb PubMed search [3] [4]
Wikidata
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Function

CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. Coexpression of this protein with dominant negative mutant CDC42 protein in fibroblast was found to induce pseudopodia formation, which suggested a role of this protein in actin filament assembly and cell shape control.^[7]

Interactions

CDC42EP2 has been shown to interact with CDC42^[5][6] and RHOQ.^[5]