CDC42EP3

Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene.^[5][6][7]

CDC42EP3
Identifiers
Aliases	CDC42EP3, BORG2, CEP3, UB1, CDC42 effector protein 3
External IDs	OMIM: 606133; MGI: 2384718; HomoloGene: 4708; GeneCards: CDC42EP3; OMA:CDC42EP3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p22.2 Start 37,641,882 bp[1] End 37,738,468 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E3 Start 79,641,156 bp[2] End 79,662,520 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia monocyte seminal vesicula myocardium of left ventricle glomerulus metanephric glomerulus saphenous vein right ventricle tail of epididymis myometrium Top expressed in spermatocyte condyle tibiofemoral joint tunica media of zone of aorta granulocyte vas deferens urinary bladder seminiferous tubule calvaria ascending aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity cytoskeletal regulatory protein binding protein binding Cellular component cytoplasm cytosol cytoskeleton membrane endomembrane system actin cytoskeleton plasma membrane Biological process positive regulation of pseudopodium assembly positive regulation of actin filament polymerization Rho protein signal transduction signal transduction regulation of cell shape positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10602 260409 Ensembl ENSG00000163171 ENSMUSG00000036533 UniProt Q9UKI2 Q9CQC5 RefSeq (mRNA) NM_001270436 NM_001270437 NM_001270438 NM_006449 NM_001371569 NM_001371570 NM_026514 RefSeq (protein) NP_001257365 NP_001257366 NP_001257367 NP_006440 NP_001358498 NP_001358499 NP_080790 Location (UCSC) Chr 2: 37.64 – 37.74 Mb Chr 17: 79.64 – 79.66 Mb PubMed search [3] [4]
Wikidata
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CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. This protein can interact with CDC42, as well as with the ras homolog gene family, member Q (ARHQ/TC10). Expression of this protein in fibroblasts has been shown to induce pseudopodia formation.^[7]

Interactions

CDC42EP3 has been shown to interact with CDC42^[5][8] and RHOQ.^[8]