CDCA5

Sororin is a protein that in humans is encoded by the CDCA5 gene.^[5][6][7]

WP:SE

CDCA5
Identifiers
Aliases	CDCA5, SORORIN, cell division cycle associated 5
External IDs	OMIM: 609374; MGI: 1915099; HomoloGene: 49860; GeneCards: CDCA5; OMA:CDCA5 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,066,300 bp[1] End 65,084,164 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 6,135,013 bp[2] End 6,141,807 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ventricular zone right testis left testis ganglionic eminence mucosa of transverse colon testicle bone marrow secondary oocyte appendix Top expressed in primary oocyte zygote secondary oocyte primitive streak fetal liver hematopoietic progenitor cell internal carotid artery Paneth cell otic placode somite external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chromatin binding protein binding protein-containing complex binding Cellular component cytoplasm cytosol cohesin complex chromosome nucleoplasm chromatin chromosome, centromeric region nucleus Biological process mitotic chromosome condensation positive regulation of exit from mitosis regulation of cohesin loading cell division mitotic sister chromatid cohesion double-strand break repair cell cycle mitotic metaphase plate congression mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 113130 67849 Ensembl ENSG00000146670 ENSMUSG00000024791 UniProt Q96FF9 Q9CPY3 RefSeq (mRNA) NM_080668 NM_026410 RefSeq (protein) NP_542399 NP_080686 Location (UCSC) Chr 11: 65.07 – 65.08 Mb Chr 19: 6.14 – 6.14 Mb PubMed search [3] [4]
Wikidata
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Function

Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.^[8]

Clinical significance

Transactivation of Sororin and its phosphorylation at Ser209 by ERK play an important role in lung cancer proliferation.^[9]