CDCP1

CUB domain-containing protein 1 (CDCP1) is a protein that in humans is encoded by the CDCP1 gene.^[5][6] CDCP1 has also been designated as CD318 (cluster of differentiation 318) and Trask (Transmembrane and associated with src kinases). Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[6]

CDCP1
Identifiers
Aliases	CDCP1, CD318, SIMA135, TRASK, CUB domain containing protein 1
External IDs	OMIM: 611735; MGI: 2442010; HomoloGene: 11276; GeneCards: CDCP1; OMA:CDCP1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 45,082,277 bp[1] End 45,146,422 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F4 Start 122,999,889 bp[2] End 123,045,103 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium islet of Langerhans mucosa of esophagus mucosa of transverse colon rectum cartilage tissue hair follicle pancreatic ductal cell duodenum palpebral conjunctiva Top expressed in Paneth cell conjunctival fornix corneal stroma lactiferous gland Ileal epithelium gastric mucosa mucous cell of stomach epithelium of stomach jejunum duodenum More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 64866 109332 Ensembl ENSG00000163814 ENSMUSG00000035498 UniProt Q9H5V8 Q5U462 RefSeq (mRNA) NM_022842 NM_178181 NM_133974 RefSeq (protein) NP_073753 NP_835488 NP_598735 Location (UCSC) Chr 3: 45.08 – 45.15 Mb Chr 9: 123 – 123.05 Mb PubMed search [3] [4]
Wikidata
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Function

CDCP1 is a 140 kD transmembrane glycoprotein with a large extracellular domain (ECD) containing two CUB domains, and a smaller intracellular domain (ICD). CDCP1 is cleaved by serine proteases at the extracellular domain next to Arg368 to generate a truncated molecule of 80 kDa size.^[7] Different cell lines express different amounts of p140 and p80, depending on the activity of endogenous serine proteases.

The intracellular domain of CDCP1 contains five tyrosine residues - Y707, Y734, Y743, Y762 and Y806. The tyrosine phosphorylation of CDCP1 in cultured cells occurs when cells are induced to detach by trypsin or EDTA, or seen spontaneously during mitotic detachment.

Clinical significance

The phosphorylation of CDCP1 is seen in many cancers, including some pre-invasive cancers as well as in invasive tumors and in tumor metastases.^[8]