CDH11

Cadherin-11 is a protein that in humans is encoded by the CDH11 gene.^[5][6]

CDH11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2A4C, 2A4E
Identifiers
Aliases	CDH11, CAD11, CDHOB, OB, OSF-4, cadherin 11, ESWS, TBHS2
External IDs	OMIM: 600023; MGI: 99217; HomoloGene: 1361; GeneCards: CDH11; OMA:CDH11 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q21 Start 64,943,753 bp[1] End 65,126,112 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 D1|8 50.44 cM Start 103,358,727 bp[2] End 103,512,274 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in periodontal fiber stromal cell of endometrium tibia visceral pleura Achilles tendon decidua left ovary right ovary germinal epithelium smooth muscle tissue Top expressed in calvaria vas deferens dermis body of femur Gonadal ridge efferent ductule human fetus left lung lobe maxillary prominence molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding calcium ion binding cytoskeletal protein binding protein homodimerization activity cadherin binding Cellular component plasma membrane membrane cytoplasm integral component of membrane extracellular exosome cell surface catenin complex synapse Schaffer collateral - CA1 synapse glutamatergic synapse Biological process homophilic cell adhesion via plasma membrane adhesion molecules skeletal system development adherens junction organization ossification corticospinal tract morphogenesis cell adhesion cell morphogenesis cell-cell junction assembly calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell-cell adhesion mediated by cadherin modulation of chemical synaptic transmission cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1009 12552 Ensembl ENSG00000140937 ENSMUSG00000031673 UniProt P55287 P55288 RefSeq (mRNA) NM_001308392 NM_001797 NM_001330576 NM_033664 NM_009866 RefSeq (protein) NP_001295321 NP_001317505 NP_001788 NP_033996 Location (UCSC) Chr 16: 64.94 – 65.13 Mb Chr 8: 103.36 – 103.51 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.^[6] The mammalian CDH-11 homologues are termed calsyntenin.^[7]

Relevance to cancer

CDH11 is overexpressed in 15% of breast cancers and seems essential to tumour progression in some other cancer types.^[8][9]

Drug interactions

Arthritis drug celecoxib binds to CDH11.^[8][9]

Interactions

CDH11 has been shown to interact with CDH2.^[10]