CDH15

Cadherin-15 is a protein that in humans is encoded by the CDH15 gene.^[5][6]

CDH15
Identifiers
Aliases	CDH15, CDH14, CDH3, CDHM, MCAD, MRD3, cadherin 15
External IDs	OMIM: 114019; MGI: 106672; HomoloGene: 3622; GeneCards: CDH15; OMA:CDH15 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q24.3 Start 89,171,748 bp[1] End 89,195,492 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 E1|8 71.99 cM Start 123,574,705 bp[2] End 123,594,136 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum gastrocnemius muscle muscle of thigh Skeletal muscle tissue of rectus abdominis glutes tibialis anterior muscle deltoid muscle paraflocculus of cerebellum tibia Top expressed in myotome muscle of thigh lumbar spinal ganglion temporal muscle triceps brachii muscle vastus lateralis muscle body of femur ankle internal carotid artery sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein binding metal ion binding cytoskeletal protein binding protein homodimerization activity cadherin binding Cellular component caveola integral component of membrane neuromuscular junction plasma membrane extracellular exosome membrane Golgi apparatus cytosol cell surface catenin complex Biological process cell adhesion adherens junction organization positive regulation of muscle cell differentiation homophilic cell adhesion via plasma membrane adhesion molecules cell morphogenesis cell-cell junction assembly calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell-cell adhesion mediated by cadherin cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1013 12555 Ensembl ENSG00000129910 ENSMUSG00000031962 UniProt P55291 P33146 RefSeq (mRNA) NM_004933 NM_007662 RefSeq (protein) NP_004924 NP_031688 Location (UCSC) Chr 16: 89.17 – 89.2 Mb Chr 8: 123.57 – 123.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.^[6]

Interactions

CDH15 has been shown to interact with ARVCF.^[7]