CDH4

Cadherin-4 is a protein that in humans is encoded by the CDH4 gene.^[5][6][7]

CDH4
Identifiers
Aliases	CDH4, CAD4, R-CAD, RCAD, cadherin 4
External IDs	OMIM: 603006; MGI: 99218; HomoloGene: 48044; GeneCards: CDH4; OMA:CDH4 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 61,252,261 bp[1] End 61,940,617 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H4|2 101.86 cM Start 179,084,224 bp[2] End 179,541,166 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence nucleus accumbens Temporal Lobe Amygdala caudate nucleus anterior cingulate cortex putamen testicle prefrontal cortex Top expressed in Bowman's capsule saccule anterior amygdaloid area coelomic epithelium epithelium of lens glomerulus gastrula olfactory bulb ganglionic eminence otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding metal ion binding cytoskeletal protein binding protein homodimerization activity cadherin binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane cell surface catenin complex Biological process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion positive regulation of axon extension adherens junction organization homophilic cell adhesion via plasma membrane adhesion molecules axon guidance cell-cell junction assembly calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell-cell adhesion mediated by cadherin cell-cell adhesion cell morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1002 12561 Ensembl ENSG00000280641 ENSG00000179242 ENSMUSG00000000305 UniProt P55283 P39038 RefSeq (mRNA) NM_001794 NM_001252338 NM_001252339 NM_009867 NM_001316723 RefSeq (protein) NP_001239267 NP_001239268 NP_001785 NP_001303652 NP_033997 Location (UCSC) Chr 20: 61.25 – 61.94 Mb Chr 2: 179.08 – 179.54 Mb PubMed search [3] [4]
Wikidata
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This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.^[7]

Interactions

Cadherin-4 has been shown to interact with:

• PTPmu^[8]