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CDH8
Protein-coding gene in humans From Wikipedia, the free encyclopedia
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Cadherin-8 is a protein that in humans is encoded by the CDH8 gene.[5][6][7]
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Function
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance.[7]
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Clinical significance
Disruptions of CDH8 in humans have been implicated in autism.[8][9]
References
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External links
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