CDIPT

CDP-diacylglycerol—inositol 3-phosphatidyltransferase is an enzyme that in humans is encoded by the CDIPT gene.^[5][6]

CDIPT
Identifiers
Aliases	CDIPT, PIS, PIS1, CDP-diacylglycerol--inositol 3-phosphatidyltransferase
External IDs	OMIM: 605893; MGI: 105491; HomoloGene: 7159; GeneCards: CDIPT; OMA:CDIPT - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 29,858,357 bp[1] End 29,863,414 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F3|7 69.26 cM Start 126,575,086 bp[2] End 126,579,673 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland endothelial cell Brodmann area 23 sperm middle temporal gyrus pancreatic ductal cell germinal epithelium visceral pleura parietal pleura gingival epithelium Top expressed in Paneth cell motor neuron substantia nigra retinal pigment epithelium barrel cortex seminal vesicula endocardial cushion fossa facial motor nucleus medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity phosphotransferase activity, for other substituted phosphate groups manganese ion binding alcohol binding CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity protein binding diacylglycerol binding carbohydrate binding Cellular component integral component of membrane Golgi apparatus endoplasmic reticulum membrane membrane Golgi membrane plasma membrane endoplasmic reticulum Biological process lipid metabolism CDP-diacylglycerol metabolic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10423 52858 Ensembl ENSG00000103502 ENSMUSG00000030682 UniProt O14735 Q8VDP6 RefSeq (mRNA) NM_001286585 NM_001286586 NM_006319 NM_145752 NM_026638 NM_001347656 NM_001379260 RefSeq (protein) NP_001273514 NP_001273515 NP_006310 NP_001273514.1 NP_001273515.1 NP_006310.1 NP_001334585 NP_080914 NP_001366189 Location (UCSC) Chr 16: 29.86 – 29.86 Mb Chr 7: 126.58 – 126.58 Mb PubMed search [3] [4]
Wikidata
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Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of multiple G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus.^[6]