CDK12

CDK12 cyclin-dependent kinase 12 is a protein kinase that in humans is encoded by the CDK12 gene.^[5][6][7] This enzyme is a member of cyclin-dependent kinase protein family.

CDK12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CXA, 4NST, 4UN0, 5ACB
Identifiers
Aliases	CDK12, CRK7, CRKR, CRKRS, cyclin-dependent kinase 12, cyclin dependent kinase 12
External IDs	OMIM: 615514; MGI: 1098802; HomoloGene: 128632; GeneCards: CDK12; OMA:CDK12 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 39,461,486 bp[1] End 39,564,907 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 61.75 cM Start 98,093,885 bp[2] End 98,169,330 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell sural nerve secondary oocyte epithelium of colon ganglionic eminence gastric mucosa ventricular zone Achilles tendon skin of leg tonsil Top expressed in zygote secondary oocyte ascending aorta tail of embryo Rostral migratory stream aortic valve genital tubercle granulocyte spermatocyte primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding kinase activity protein serine/threonine kinase activity protein binding RNA polymerase II CTD heptapeptide repeat kinase activity ATP binding cyclin binding cyclin-dependent protein serine/threonine kinase activity transcription factor binding protein kinase binding Cellular component nuclear speck nuclear cyclin-dependent protein kinase holoenzyme complex cyclin K-CDK12 complex nucleus nucleoplasm fibrillar center chromosome cyclin/CDK positive transcription elongation factor complex cyclin-dependent protein kinase holoenzyme complex Biological process phosphorylation of RNA polymerase II C-terminal domain phosphorylation mRNA processing regulation of cell cycle protein phosphorylation regulation of RNA splicing RNA splicing protein autophosphorylation regulation of MAP kinase activity transcription elongation from RNA polymerase II promoter positive regulation of transcription by RNA polymerase II negative regulation of stem cell differentiation positive regulation of transcription elongation from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51755 69131 Ensembl ENSG00000167258 ENSMUSG00000003119 UniProt Q9NYV4 Q14AX6 RefSeq (mRNA) NM_015083 NM_016507 NM_001109626 NM_001109628 NM_026952 RefSeq (protein) NP_055898 NP_057591 NP_001103096 NP_001103098 NP_081228 Location (UCSC) Chr 17: 39.46 – 39.56 Mb Chr 11: 98.09 – 98.17 Mb PubMed search [3] [4]
Wikidata
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