CDK2AP1

Cyclin-dependent kinase 2-associated protein 1 is an enzyme that in humans is encoded by the CDK2AP1 gene.^[5][6][7]

CDK2AP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KW6
Identifiers
Aliases	CDK2AP1, DOC1, DORC1, ST19, doc-1, p12DOC-1, cyclin-dependent kinase 2 associated protein 1, cyclin dependent kinase 2 associated protein 1
External IDs	OMIM: 602198; MGI: 1202069; HomoloGene: 3411; GeneCards: CDK2AP1; OMA:CDK2AP1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 123,250,112 bp[1] End 123,272,334 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 124,483,480 bp[2] End 124,501,145 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland tibia spinal cord C1 segment ganglionic eminence internal globus pallidus superior vestibular nucleus ventricular zone inferior ganglion of vagus nerve dorsal motor nucleus of vagus nerve Top expressed in genital tubercle tail of embryo ganglionic eminence ventricular zone epiblast morula islet of Langerhans quadriceps femoris muscle adrenal gland lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding DNA polymerase binding Cellular component perinuclear region of cytoplasm nucleus nucleoplasm cytosol Biological process DNA-dependent DNA replication cell cycle positive regulation of protein phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8099 13445 Ensembl ENSG00000111328 ENSMUSG00000029394 UniProt O14519 O35207 RefSeq (mRNA) NM_001270433 NM_001270434 NM_004642 NM_013812 RefSeq (protein) NP_001257362 NP_001257363 NP_004633 NP_038840 Location (UCSC) Chr 12: 123.25 – 123.27 Mb Chr 5: 124.48 – 124.5 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes.^[7]

Interactions

CDK2AP1 has been shown to interact with Cyclin-dependent kinase 2.^[8]

It interacts with unnamed protein product (BC006130) which may mediate inhibitory effect of CDK2AP1 on cell proliferation.^[9]