CDK5R2

Cyclin-dependent kinase 5 activator 2 is an enzyme that in humans is encoded by the CDK5R2 gene.^[5][6]

CDK5R2
Identifiers
Aliases	CDK5R2, NCK5AI, P39, p39nck5ai, cyclin-dependent kinase 5, regulatory subunit 2 (p39), cyclin dependent kinase 5 regulatory subunit 2
External IDs	OMIM: 603764; MGI: 1330828; HomoloGene: 2924; GeneCards: CDK5R2; OMA:CDK5R2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 218,959,666 bp[1] End 218,962,155 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C4 Start 74,894,093 bp[2] End 74,896,891 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex Brodmann area 9 right frontal lobe putamen nucleus accumbens cingulate gyrus anterior cingulate cortex lateral nuclear group of thalamus caudate nucleus pituitary gland Top expressed in superior frontal gyrus neural layer of retina supraoptic nucleus dentate gyrus of hippocampal formation granule cell primary visual cortex prefrontal cortex cerebellar cortex lateral septal nucleus olfactory tubercle hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cyclin-dependent protein serine/threonine kinase activator activity lipid binding actin binding Cellular component cytoplasm protein kinase 5 complex plasma membrane membrane growth cone neuron projection Biological process positive regulation of protein kinase activity regulation of cyclin-dependent protein serine/threonine kinase activity neuron migration hippocampus development layer formation in cerebral cortex cerebellum development positive regulation of protein serine/threonine kinase activity superior olivary nucleus maturation positive regulation of calcium ion-dependent exocytosis positive regulation of cyclin-dependent protein serine/threonine kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8941 12570 Ensembl ENSG00000171450 ENSMUSG00000090071 UniProt Q13319 O35926 RefSeq (mRNA) NM_003936 NM_009872 RefSeq (protein) NP_003927 NP_034002 Location (UCSC) Chr 2: 218.96 – 218.96 Mb Chr 1: 74.89 – 74.9 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase-activating proteins.^[6]

Interactions

CDK5R2 has been shown to interact with Actinin, alpha 1.^[7]