CDKL2

Cyclin-dependent kinase-like 2 is an enzyme that in humans is encoded by the CDKL2 gene.^[5][6]

CDKL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4AAA, 4BBM
Identifiers
Aliases	CDKL2, KKIAMRE, P56, cyclin dependent kinase like 2
External IDs	OMIM: 603442; MGI: 1858227; HomoloGene: 55793; GeneCards: CDKL2; OMA:CDKL2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.1 Start 75,576,496 bp[1] End 75,630,716 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E2 Start 92,006,074 bp[2] End 92,043,883 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus postcentral gyrus superior frontal gyrus testicle primary visual cortex entorhinal cortex lower lobe of lung prefrontal cortex Top expressed in barrel cortex lumbar spinal ganglion spermatocyte facial motor nucleus seminiferous tubule olfactory epithelium spermatid vestibular sensory epithelium zygote Epithelium of choroid plexus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding protein serine/threonine kinase activity ATP binding kinase activity cyclin-dependent protein serine/threonine kinase activity Cellular component cytoplasm centrosome nucleus Biological process protein phosphorylation sex differentiation phosphorylation signal transduction regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8999 53886 Ensembl ENSG00000138769 ENSMUSG00000029403 UniProt Q92772 Q9QUK0 RefSeq (mRNA) NM_003948 NM_001330724 NM_001276315 NM_016912 NM_177270 RefSeq (protein) NP_001317653 NP_003939 NP_001263244 NP_058608 NP_796244 Location (UCSC) Chr 4: 75.58 – 75.63 Mb Chr 5: 92.01 – 92.04 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus.^[6]