CDKN2BAS

CDKN2B antisense RNA 1 intronic convserved region
CDKN2B antisense RNA 1 intronic convserved region
	Predicted secondary structure and sequence conservation of CDKN2B-AS
Identifiers
Symbol	CDKN2B-AS
Alt. Symbols	ANRIL
Rfam	RF01909
Other data
RNA type	Gene;
Domain(s)	Eukaryota;
GO	GO:0006342 GO:0005515
SO	SO:0001463
PDB structures	PDBe

CDKN2B-AS1
Identifiers
Aliases	CDKN2B-AS1, ANRIL, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, p15AS, CDKN2B antisense RNA 1
External IDs	OMIM: 613149; GeneCards: CDKN2B-AS1; OMA:CDKN2B-AS1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	22,128,103 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; epithelium of colon; ; testicle; ; gonad; ; right uterine tube; ; anterior pituitary; ; pancreatic ductal cell; ; tibialis anterior muscle; ; sural nerve;
	n/a
	More reference expression data
	n/a
Orthologs
	100048912
	n/a
	ENSG00000240498
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

CDKN2B-AS, also known as ANRIL (antisense non-coding RNA in the INK4 locus) is a long non-coding RNA consisting of 19 exons, spanning 126.3kb in the genome, and its spliced product is a 3834bp RNA. It is located within the p15/CDKN2B-p16/CDKN2A-p14/ARF gene cluster, in the antisense direction. Single nucleotide polymorphisms (SNPs) which alter the expression of CDKN2B-AS are associated with human healthy life expectancy, as well as with multiple diseases, including coronary artery disease, diabetes and many cancers.^[3] It binds to chromobox 7 (CBX7) within the polycomb repressive complex 1 and to SUZ12, a component of polycomb repression complex 2 and through these interactions is involved in transcriptional repression.^[4]^[5]