CDKN2BAS

CDKN2B-AS, also known as ANRIL (antisense non-coding RNA in the INK4 locus) is a long non-coding RNA consisting of 19 exons, spanning 126.3kb in the genome, and its spliced product is a 3834bp RNA. It is located within the p15/CDKN2B-p16/CDKN2A-p14/ARF gene cluster, in the antisense direction. Single nucleotide polymorphisms (SNPs) which alter the expression of CDKN2B-AS are associated with human healthy life expectancy, as well as with multiple diseases, including coronary artery disease, diabetes and many cancers.^[3] It binds to chromobox 7 (CBX7) within the polycomb repressive complex 1 and to SUZ12, a component of polycomb repression complex 2 and through these interactions is involved in transcriptional repression.^[4][5]

CDKN2B-AS1
Identifiers
Aliases	CDKN2B-AS1, ANRIL, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, p15AS, CDKN2B antisense RNA 1
External IDs	OMIM: 613149; GeneCards: CDKN2B-AS1; OMA:CDKN2B-AS1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p21.3 Start 21,994,139 bp[1] End 22,128,103 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon rectum epithelium of colon testicle gonad right uterine tube anterior pituitary pancreatic ductal cell tibialis anterior muscle sural nerve n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 100048912 n/a Ensembl ENSG00000240498 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 9: 21.99 – 22.13 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

CDKN2B antisense RNA 1 intronic convserved region
Predicted secondary structure and sequence conservation of CDKN2B-AS
Identifiers
Symbol	CDKN2B-AS
Alt. Symbols	ANRIL
Rfam	RF01909
Other data
RNA type	Gene;
Domain(s)	Eukaryota;
GO	GO:0006342 GO:0005515
SO	SO:0001463
PDB structures	PDBe

See also

• Long noncoding RNA