CDKN2D

Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene.^[5][6]

CDKN2D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BD8, 1BI8
Identifiers
Aliases	CDKN2D, INK4D, p19, p19-INK4D, cyclin-dependent kinase inhibitor 2D, cyclin dependent kinase inhibitor 2D
External IDs	OMIM: 600927; MGI: 105387; HomoloGene: 36081; GeneCards: CDKN2D; OMA:CDKN2D - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 10,566,460 bp[1] End 10,569,059 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A3 Start 21,199,706 bp[2] End 21,202,703 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte right frontal lobe cingulate gyrus anterior cingulate cortex prefrontal cortex Amygdala nucleus accumbens dorsolateral prefrontal cortex caudate nucleus Top expressed in granulocyte tibiofemoral joint atrium thymus fetal liver hematopoietic progenitor cell medial ganglionic eminence saccule endocardial cushion human fetus cingulate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cyclin-dependent protein serine/threonine kinase inhibitor activity protein kinase binding Cellular component cytoplasm nucleoplasm nucleus cytosol cyclin D2-CDK4 complex Biological process DNA synthesis involved in DNA repair regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to vitamin D response to retinoic acid negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of cell growth cell cycle negative regulation of phosphorylation response to UV autophagic cell death negative regulation of cell population proliferation hearing negative regulation of cell cycle G1/S phase transition G1/S transition of mitotic cell cycle negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1032 12581 Ensembl ENSG00000129355 ENSMUSG00000096472 UniProt P55273 Q60773 RefSeq (mRNA) NM_079421 NM_001800 NM_009878 RefSeq (protein) NP_001791 NP_524145 NP_034008 Location (UCSC) Chr 19: 10.57 – 10.57 Mb Chr 9: 21.2 – 21.2 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. The expression of this gene and its protein product (p19) is observed in neurons with neurofibrillary tangles (NFTs) and it is suggested as a marker for senescent neurons.^[7] Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.^[6]

Note, this protein should not be confused with p19-ARF (mouse) or the human equivalent p14ARF, which are alternative products of the CDKN2A gene.