CDS2

For the aerodrome using the TC LID, CDS2, see Disley Aerodrome.

Phosphatidate cytidylyltransferase 2 is an enzyme that in humans is encoded by the CDS2 gene.^[5][6][7]

CDS2
Identifiers
Aliases	CDS2, CDP-diacylglycerol synthase 2
External IDs	OMIM: 603549; MGI: 1332236; HomoloGene: 37854; GeneCards: CDS2; OMA:CDS2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p12.3 Start 5,126,879 bp[1] End 5,197,887 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F2|2 64.15 cM Start 132,105,068 bp[2] End 132,153,970 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus middle temporal gyrus pars compacta pars reticulata postcentral gyrus spinal ganglia entorhinal cortex superior vestibular nucleus external globus pallidus ventral tegmental area Top expressed in motor neuron substantia nigra facial motor nucleus habenula Epithelium of choroid plexus renal corpuscle ciliary body deep cerebellar nuclei medial vestibular nucleus medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity transferase activity, transferring phosphorus-containing groups nucleotidyltransferase activity phosphatidate cytidylyltransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane mitochondrion endoplasmic reticulum membrane mitochondrial inner membrane Biological process phosphatidylglycerol biosynthetic process CDP-diacylglycerol biosynthetic process lipid metabolism phospholipid biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8760 110911 Ensembl ENSG00000101290 ENSMUSG00000058793 UniProt O95674 Q99L43 RefSeq (mRNA) NM_003818 NM_001291039 NM_001291040 NM_138651 RefSeq (protein) NP_003809 NP_001277968 NP_001277969 NP_619592 Location (UCSC) Chr 20: 5.13 – 5.2 Mb Chr 2: 132.11 – 132.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin.^[8][9] and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 (CDS1) and a second (this gene) to 20p13.^[10]