CDYL2

Chromodomain protein, Y-like 2 is a protein in humans that is encoded by the CDYL2 gene. It localizes to the nucleus, where it acts as a chromatin reader recognizing trimethylation of Histone H3 lysine 9 and repressing transcription. ^[5]

CDYL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MJ8, 4HAE, 5JJZ
Identifiers
Aliases	CDYL2, PCCP1, chromodomain protein, Y-like 2, chromodomain Y like 2
External IDs	MGI: 1923046; HomoloGene: 41779; GeneCards: CDYL2; OMA:CDYL2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q23.2 Start 80,597,907 bp[1] End 80,804,598 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 117,301,139 bp[2] End 117,459,730 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis placenta mucosa of ileum middle temporal gyrus Brodmann area 46 testicle Brodmann area 23 pancreatic epithelial cell jejunal mucosa tail of epididymis Top expressed in blastocyst morula spermatid granulocyte embryo zygote right kidney seminiferous tubule embryo thymus More reference expression data BioGPS n/a
Gene ontology Molecular function catalytic activity protein binding methylated histone binding transcription corepressor activity Cellular component nucleus Biological process metabolism negative regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 124359 75796 Ensembl ENSG00000166446 ENSMUSG00000031758 UniProt Q8N8U2 Q9D5D8 RefSeq (mRNA) NM_152342 NM_029441 RefSeq (protein) NP_689555 NP_083717 Location (UCSC) Chr 16: 80.6 – 80.8 Mb Chr 8: 117.3 – 117.46 Mb PubMed search [3] [4]
Wikidata
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