CEBPD

CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene.^[5][6]

CEBPD
Identifiers
Aliases	CEBPD, C/EBP-delta, CELF, CRP3, NF-IL6-beta, CCAAT/enhancer binding protein delta, CCAAT enhancer binding protein delta
External IDs	OMIM: 116898; MGI: 103573; HomoloGene: 3808; GeneCards: CEBPD; OMA:CEBPD - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q11.21 Start 47,736,913 bp[1] End 47,738,164 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A2|16 10.09 cM Start 15,705,150 bp[2] End 15,708,895 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium vena cava lower lobe of lung trachea cardia beta cell mucosa of paranasal sinus olfactory bulb cartilage tissue gastric mucosa Top expressed in left lung lobe granulocyte umbilical cord endothelial cell of lymphatic vessel gastrula right lung muscle of thigh carotid body ankle ankle joint More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity, RNA polymerase II-specific protein homodimerization activity protein heterodimerization activity Cellular component nucleus nucleoplasm Biological process regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II cytokine-mediated signaling pathway hematopoietic progenitor cell differentiation regulation of transcription by RNA polymerase II fat cell differentiation positive regulation of osteoblast differentiation negative regulation of transcription, DNA-templated inner ear development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1052 12609 Ensembl ENSG00000221869 ENSMUSG00000071637 UniProt P49716 Q00322 RefSeq (mRNA) NM_005195 NM_007679 RefSeq (protein) NP_005186 NP_031705 Location (UCSC) Chr 8: 47.74 – 47.74 Mb Chr 16: 15.71 – 15.71 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.^[7]

Functions

CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor.^[8]

One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy.^[9]

Function of CEBPD gene can be effectively examined by siRNA knockdown based on an independent validation.^[10]

Interactions

CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.^[11]

See also

• Ccaat-enhancer-binding proteins