CELA2B

Chymotrypsin-like elastase family member 2B is and enzyme that in humans is encoded by the CELA2B gene.^[3][4][5]

CELA2B
Identifiers
Aliases	CELA2B, ELA2B, chymotrypsin like elastase family member 2B, chymotrypsin like elastase 2B
External IDs	OMIM: 609444; HomoloGene: 88835; GeneCards: CELA2B; OMA:CELA2B - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.21 Start 15,465,909 bp[1] End 15,491,395 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas testicle islet of Langerhans pancreatic epithelial cell pancreatic ductal cell left adrenal cortex right adrenal cortex right hemisphere of cerebellum left ovary stromal cell of endometrium n/a More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity Cellular component extracellular region extracellular space Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51032 n/a Ensembl ENSG00000215704 n/a UniProt P08218 n/a RefSeq (mRNA) NM_015849 n/a RefSeq (protein) NP_056933 n/a Location (UCSC) Chr 1: 15.47 – 15.49 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues.^[5]