CELA3A

Chymotrypsin-like elastase family member 3A is an enzyme that in humans is encoded by the CELA3A gene.^[5][6][7]

CELA3A
Identifiers
Aliases	CELA3A, ELA3, ELA3A, chymotrypsin like elastase family member 3A, chymotrypsin like elastase 3A
External IDs	MGI: 3651647; HomoloGene: 129880; GeneCards: CELA3A; OMA:CELA3A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.12 Start 22,001,657 bp[1] End 22,012,542 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 137,128,865 bp[2] End 137,137,102 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas islet of Langerhans duodenum body of stomach fundus right coronary artery ectocervix right uterine tube canal of the cervix right adrenal gland Top expressed in islet of Langerhans colon stomach nervous system brain human kidney More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity Cellular component extracellular space Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10136 242711 Ensembl ENSG00000142789 ENSMUSG00000078520 UniProt P09093 A2A9U8 RefSeq (mRNA) NM_005747 NM_001126318 RefSeq (protein) NP_005738 NP_001119790 Location (UCSC) Chr 1: 22 – 22.01 Mb Chr 4: 137.13 – 137.14 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1.^[7]