CELSR1

Cadherin EGF LAG seven-pass G-type receptor 1 also known as flamingo homolog 2 or cadherin family member 9 is a protein that in humans is encoded by the CELSR1 gene.^[5][6]

CELSR1
Identifiers
Aliases	CELSR1, CDHF9, FMI2, HFMI2, ME2, ADGRC1, cadherin EGF LAG seven-pass G-type receptor 1, LMPHM9
External IDs	OMIM: 604523; MGI: 1100883; HomoloGene: 7665; GeneCards: CELSR1; OMA:CELSR1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.31 Start 46,360,834 bp[1] End 46,537,620 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E2|15 40.42 cM Start 85,783,130 bp[2] End 85,918,404 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone bronchial epithelial cell right uterine tube olfactory zone of nasal mucosa ganglionic eminence skin of abdomen anterior pituitary skin of leg secondary oocyte mucosa of paranasal sinus Top expressed in ventricular zone molar vestibular sensory epithelium hair follicle lip medullary collecting duct skin of external ear tail of embryo secondary oocyte primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding G protein-coupled receptor activity protein dimerization activity signal transducer activity transmembrane signaling receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane nucleoplasm Biological process hair follicle development planar dichotomous subdivision of terminal units involved in lung branching morphogenesis G protein-coupled receptor signaling pathway lateral sprouting involved in lung morphogenesis regulation of actin cytoskeleton organization locomotory behavior orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis establishment of planar polarity of embryonic epithelium establishment of planar polarity wound healing neuron migration establishment of body hair planar orientation planar cell polarity pathway involved in neural tube closure multicellular organism development Wnt signaling pathway, planar cell polarity pathway central nervous system development cell surface receptor signaling pathway neural tube closure cell adhesion inner ear morphogenesis apical protein localization Rho protein signal transduction anterior/posterior pattern specification signal transduction homophilic cell adhesion via plasma membrane adhesion molecules protein localization involved in establishment of planar polarity cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9620 12614 Ensembl ENSG00000075275 ENSMUSG00000016028 UniProt Q9NYQ6 O35161 RefSeq (mRNA) NM_014246 NM_001378328 NM_009886 RefSeq (protein) NP_055061 NP_001365257 NP_034016 Location (UCSC) Chr 22: 46.36 – 46.54 Mb Chr 15: 85.78 – 85.92 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin G-like domains in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis.^[6]

See also

• Flamingo (protein)