CENPI

Centromere protein I is a protein that in humans is encoded by the CENPI gene.^[5][6]

CENPI
Identifiers
Aliases	CENPI, CENP-I, FSHPRH1, LRPR1, Mis6, centromere protein I
External IDs	OMIM: 300065; MGI: 2147897; HomoloGene: 4899; GeneCards: CENPI; OMA:CENPI - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.1 Start 101,098,188 bp[1] End 101,166,126 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X E3 Start 133,208,833 bp[2] End 133,263,388 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ventricular zone gonad ganglionic eminence testicle stromal cell of endometrium smooth muscle tissue bone marrow rectum trabecular bone Top expressed in hand tail of embryo dermis genital tubercle otic vesicle abdominal wall endothelial cell of lymphatic vessel ventricular zone renal corpuscle spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component chromosome chromosome, centromeric region nucleoplasm kinetochore nucleus cytosol nuclear body Biological process sex differentiation centromere complex assembly CENP-A containing chromatin assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2491 102920 Ensembl ENSG00000102384 ENSMUSG00000031262 UniProt Q92674 Q8K1K4 RefSeq (mRNA) NM_006733 NM_001318521 NM_001318523 NM_001386188 NM_145924 NM_001305631 RefSeq (protein) NP_001305450 NP_001305452 NP_006724 NP_001292560 NP_666036 Location (UCSC) Chr X: 101.1 – 101.17 Mb Chr X: 133.21 – 133.26 Mb PubMed search [3] [4]
Wikidata
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Function

The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis.^[6] CENPI is a target gene of the transcription factor E2F.^[7] Additionally, CENPI expression is increased in breast cancer and this has been shown to cause chromosome instability in breast cancer cells.^[7]