CENPM

Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by the CENPM gene.^[5][6][7]

CENPM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4P0T, 4WAU
Identifiers
Aliases	CENPM, C22orf18, CENP-M, PANE1, bK250D10.2, centromere protein M
External IDs	OMIM: 610152; MGI: 1913820; HomoloGene: 11438; GeneCards: CENPM; OMA:CENPM - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.2 Start 41,938,737 bp[1] End 41,947,152 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 82,117,980 bp[2] End 82,128,949 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right uterine tube gonad ventricular zone ganglionic eminence epithelium of bronchus bronchial epithelial cell testicle bone marrow appendix Top expressed in morula ventricular zone primary oocyte secondary oocyte embryo embryo medial ganglionic eminence zygote yolk sac fetal liver hematopoietic progenitor cell More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 79019 66570 Ensembl ENSG00000100162 ENSMUSG00000068101 UniProt Q9NSP4 Q9CQA0 RefSeq (mRNA) NM_001002876 NM_001110215 NM_001304370 NM_001304371 NM_001304372 NM_001304373 NM_024053 NM_001080158 NM_025639 NM_178269 RefSeq (protein) NP_001002876 NP_001103685 NP_001291299 NP_001291300 NP_001291301 NP_001291302 NP_076958 NP_001073627 NP_079915 NP_840000 Location (UCSC) Chr 22: 41.94 – 41.95 Mb Chr 15: 82.12 – 82.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

An alternative transcript of the CENPM gene encodes a leukocyte antigen that is selectively expressed in B-lymphoid cells.^[8][9] Centromere protein M is involved in centromere assembly and immune response.^[10]