CENPO

Centromere protein O is a protein that in humans is encoded by the CENPO gene.^[5][6][7] CENPO is involved in cell proliferation and cell cycle progression and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and neuroblasts and a severe reduction in numbers of neurons produced. ^[8]

CENPO
Identifiers
Aliases	CENPO, CENP-O, ICEN-36, MCM21R, centromere protein O
External IDs	OMIM: 611504; MGI: 1923800; HomoloGene: 49760; GeneCards: CENPO; OMA:CENPO - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.3 Start 24,793,136 bp[1] End 24,822,376 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 A1.1|12 2.02 cM Start 4,246,004 bp[2] End 4,284,294 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence testicle gonad secondary oocyte left testis right testis stromal cell of endometrium mucosa of transverse colon right adrenal cortex Top expressed in primary oocyte zygote secondary oocyte otic vesicle spermatocyte otic placode saccule lumbar subsegment of spinal cord Paneth cell primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component chromosome cytosol chromosome, centromeric region kinetochore nucleoplasm nucleus Mis6-Sim4 complex Biological process centromere complex assembly CENP-A containing chromatin assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79172 52504 Ensembl ENSG00000138092 ENSMUSG00000020652 UniProt Q9BU64 Q8K015 RefSeq (mRNA) NM_001199803 NM_024322 NM_001322101 NM_134046 NM_001361641 RefSeq (protein) NP_001186732 NP_001309030 NP_077298 NP_598807 NP_001348570 Location (UCSC) Chr 2: 24.79 – 24.82 Mb Chr 12: 4.25 – 4.28 Mb PubMed search [3] [4]
Wikidata
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