CENTG1

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the AGAP2 gene.^[5]

AGAP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BMJ, 2IWR, 2RLO
Identifiers
Aliases	AGAP2, CENTG1, GGAP2, PIKE, ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
External IDs	OMIM: 605476; MGI: 3580016; HomoloGene: 86815; GeneCards: AGAP2; OMA:AGAP2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q14.1 Start 57,723,761 bp[1] End 57,742,157 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 126,911,153 bp[2] End 126,929,038 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe cingulate gyrus anterior cingulate cortex nucleus accumbens amygdala prefrontal cortex caudate nucleus Brodmann area 9 putamen Top expressed in striatum of neuraxis superior frontal gyrus primary visual cortex hippocampus proper olfactory bulb dentate gyrus of hippocampal formation granule cell cerebellar cortex hypothalamus granulocyte thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity metal ion binding nucleotide binding GTP binding protein binding GTPase activity Cellular component extracellular exosome membrane nucleolus cytoplasm mitochondrion nucleus Biological process negative regulation of neuron apoptotic process protein transport negative regulation of protein catabolic process positive regulation of GTPase activity transport positive regulation of 1-phosphatidylinositol-3-kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 116986 216439 Ensembl ENSG00000135439 ENSMUSG00000025422 UniProt Q99490 Q3UHD9 RefSeq (mRNA) NM_001122772 NM_014770 NM_001033263 NM_001301014 RefSeq (protein) NP_001116244 NP_055585 NP_001028435 NP_001287943 Location (UCSC) Chr 12: 57.72 – 57.74 Mb Chr 10: 126.91 – 126.93 Mb PubMed search [3] [4]
Wikidata
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Interactions

CENTG1 has been shown to interact with:

• EPB41L1,^[6]
• HOMER1^[7] and
• PIK3R1.^[6]