CENTG3

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 is an enzyme that in humans is encoded by the AGAP3 gene.^[5]

AGAP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IHW
Identifiers
Aliases	AGAP3, AGAP-3, CENTG3, CRAG, MRIP-1, cnt-g3, ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
External IDs	OMIM: 616813; MGI: 2183446; HomoloGene: 23742; GeneCards: AGAP3; OMA:AGAP3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q36.1 Start 151,085,831 bp[1] End 151,144,436 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 A3 Start 24,657,175 bp[2] End 24,707,045 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe Brodmann area 9 cingulate gyrus anterior cingulate cortex prefrontal cortex amygdala hypothalamus nucleus accumbens anterior pituitary Top expressed in superior frontal gyrus dentate gyrus of hippocampal formation granule cell primary visual cortex neural layer of retina ventricular zone lip muscle of thigh cerebellar cortex otic vesicle saccule More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding metal ion binding GTPase activator activity GTPase activity polyubiquitin modification-dependent protein binding Cellular component membrane nucleus cytoplasm cell periphery Biological process positive regulation of GTPase activity signal transduction cellular response to reactive oxygen species proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 116988 213990 Ensembl ENSG00000133612 ENSMUSG00000023353 UniProt Q96P47 Q86ST5 Q8VHH5 RefSeq (mRNA) NM_001042535 NM_001281300 NM_001308304 NM_001308305 NM_031946 NM_001350102 NM_001350103 NM_001350104 NM_001256431 NM_139153 NM_001359881 RefSeq (protein) NP_001036000 NP_001268229 NP_001295233 NP_001295234 NP_114152 NP_001337031 NP_001337032 NP_001337033 NP_001036000.1 NP_001295233.1 NP_001295234.1 n/a Location (UCSC) Chr 7: 151.09 – 151.14 Mb Chr 5: 24.66 – 24.71 Mb PubMed search [3] [4]
Wikidata
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