CEP120

Centrosomal protein of 120 kDa (Cep120), also known as coiled-coil domain-containing protein 100, is a protein that in humans is encoded by the CEP120 gene.^[5][6]

CEP120
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ICW, 4ICX
Identifiers
Aliases	CEP120, CCDC100, SRTD13, centrosomal protein 120, JBTS31
External IDs	OMIM: 613446; MGI: 2147298; HomoloGene: 27415; GeneCards: CEP120; OMA:CEP120 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q23.2 Start 123,344,885 bp[1] End 123,423,592 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 D1 Start 53,814,795 bp[2] End 53,877,680 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon pancreatic epithelial cell mucosa of paranasal sinus thymus germinal epithelium superficial temporal artery synovial membrane secondary oocyte cardiac muscle tissue of right atrium epithelium of lactiferous gland Top expressed in superior cervical ganglion interventricular septum secondary oocyte zygote neural layer of retina hand primary oocyte spermatocyte seminiferous tubule spermatid More reference expression data BioGPS n/a
Gene ontology Molecular function protein C-terminus binding protein binding Cellular component cytoplasm microtubule organizing center centrosome cytoskeleton centriole Biological process regulation of protein localization interkinetic nuclear migration neurogenesis cell population proliferation regulation of microtubule-based process astral microtubule organization microtubule cytoskeleton organization cerebral cortex development positive regulation of cilium assembly positive regulation of centrosome duplication centrosome cycle positive regulation of centriole elongation positive regulation of establishment of protein localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 153241 225523 Ensembl ENSG00000168944 ENSMUSG00000048799 UniProt Q8N960 Q7TSG1 RefSeq (mRNA) NM_001166226 NM_153223 NM_178686 RefSeq (protein) NP_001159698 NP_694955 NP_001362334 NP_001362335 NP_001362336 NP_001362337 NP_001362338 NP_848801 Location (UCSC) Chr 5: 123.34 – 123.42 Mb Chr 18: 53.81 – 53.88 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar protein in mouse plays a role in both interkinetic nuclear migration, which is a characteristic pattern of nuclear movement in neural progenitors, and in neural progenitor self-renewal. Mutations in this gene are predicted to result in neurogenic defects.^[5]