CEP250

Centrosome-associated protein CEP250 is a protein that in humans is encoded by the CEP250 gene.^[5][6][7] This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome.^[7] Furthermore, CEP135 is also required for the centriolar localization of CEP250.^[8]

CEP250
Identifiers
Aliases	CEP250, C-NAP1, CEP2, CNAP1, centrosomal protein 250, CRDHL2
External IDs	OMIM: 609689; MGI: 108084; HomoloGene: 38286; GeneCards: CEP250; OMA:CEP250 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.22 Start 35,455,164 bp[1] End 35,519,280 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 155,798,378 bp[2] End 155,840,820 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve ventricular zone granulocyte ganglionic eminence stromal cell of endometrium cerebellar hemisphere right hemisphere of cerebellum Achilles tendon lymph node epithelium of colon Top expressed in neural layer of retina granulocyte tail of embryo ventricular zone genital tubercle yolk sac thymus Jacobson's organ zygote secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein domain specific binding protein C-terminus binding protein binding protein kinase binding Cellular component cytoplasm cytosol centrosome cell projection cilium microtubule organizing center perinuclear region of cytoplasm centriole extracellular exosome cytoskeleton protein-containing complex Biological process protein localization to organelle protein localization regulation of centriole-centriole cohesion centriole-centriole cohesion G2/M transition of mitotic cell cycle cell cycle mitotic cell cycle ciliary basal body-plasma membrane docking positive regulation of protein localization to centrosome non-motile cilium assembly regulation of G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11190 16328 Ensembl ENSG00000126001 ENSMUSG00000038241 UniProt Q9BV73 Q60952 RefSeq (mRNA) NM_001035518 NM_007186 NM_001318219 NM_001129999 NM_001130000 NM_008383 NM_177217 RefSeq (protein) NP_001305148 NP_009117 NP_001123471 NP_001123472 NP_032409 NP_796191 Location (UCSC) Chr 20: 35.46 – 35.52 Mb Chr 2: 155.8 – 155.84 Mb PubMed search [3] [4]
Wikidata
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