CEP350

Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350 gene.^[5][6][7]

CEP350
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2COZ
Identifiers
Aliases	CEP350, CAP350, GM133, centrosomal protein 350
External IDs	OMIM: 617870; MGI: 1921331; HomoloGene: 8879; GeneCards: CEP350; OMA:CEP350 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.2 Start 179,954,773 bp[1] End 180,114,875 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 G3 Start 155,720,710 bp[2] End 155,849,001 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm trabecular bone nipple left testis Achilles tendon right testis optic nerve pancreatic ductal cell jejunal mucosa gingival epithelium Top expressed in medullary collecting duct epithelium of stomach ciliary body pyloric antrum retinal pigment epithelium triceps brachii muscle vastus lateralis muscle Epithelium of choroid plexus temporal muscle mucous cell of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding protein binding Cellular component centrosome spindle cytoskeleton membrane nucleus microtubule organizing center cytoplasm cell projection centriole Biological process microtubule anchoring Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9857 74081 Ensembl ENSG00000135837 ENSMUSG00000033671 UniProt Q5VT06 E9Q309 RefSeq (mRNA) NM_014810 NM_001039184 RefSeq (protein) NP_055625 NP_001034273 Location (UCSC) Chr 1: 179.95 – 180.11 Mb Chr 1: 155.72 – 155.85 Mb PubMed search [3] [4]
Wikidata
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CEP350 is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. It primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. CEP350 is required to anchor microtubules at the centrosome. Furthermore, it increases the stability of growing centrioles.^[8]

It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined.^[7]