CEP57

Centrosomal protein of 57 kDa is a protein that in humans is encoded by the CEP57 gene.^[5][6] It is also known as translokin.

CEP57
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4L0R
Identifiers
Aliases	CEP57, MVA2, PIG8, TSP57, centrosomal protein 57
External IDs	OMIM: 607951; MGI: 1915551; HomoloGene: 8790; GeneCards: CEP57; OMA:CEP57 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q21 Start 95,789,965 bp[1] End 95,832,693 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A1 Start 13,719,088 bp[2] End 13,738,403 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte Achilles tendon sperm ganglionic eminence secondary oocyte gallbladder hair follicle ventricular zone Epithelium of choroid plexus cartilage tissue Top expressed in seminiferous tubule hand spermatid genital tubercle tail of embryo spermatocyte ventricular zone epiblast abdominal wall thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity microtubule binding protein binding identical protein binding fibroblast growth factor binding gamma-tubulin binding Cellular component cytosol centrosome Golgi apparatus microtubule organizing center microtubule cytoskeleton nucleus cytoplasm microtubule cytoskeleton nucleoplasm Biological process fibroblast growth factor receptor signaling pathway microtubule anchoring G2/M transition of mitotic cell cycle spermatid development mitotic sister chromatid segregation protein homooligomerization ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9702 74360 Ensembl ENSG00000166037 ENSMUSG00000031922 UniProt Q86XR8 Q8CEE0 RefSeq (mRNA) NM_001243776 NM_001243777 NM_014679 NM_001363604 NM_026665 NM_001310721 RefSeq (protein) NP_001230705 NP_001230706 NP_055494 NP_001350533 NP_001297650 NP_080941 Location (UCSC) Chr 11: 95.79 – 95.83 Mb Chr 9: 13.72 – 13.74 Mb PubMed search [3] [4]
Wikidata
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Translokin binds basic fibroblast growth factor (FGF2; MIM 134920) and mediates its nuclear translocation and mitogenic activity (Bossard et al., 2003).[supplied by OMIM]^[6]