Carboxylesterase 2

"CES2" redirects here. For the airport in Quebec, see Saint-Esprit Aerodrome.

Carboxylesterase 2 is an enzyme that in humans is encoded by the CES2 gene.^[5][6][7] It is a member of the alpha/beta fold hydrolase family.^[8]

CES2
Identifiers
Aliases	CES2, CE-2, CES2A1, PCE-2, iCE, Carboxylesterase 2, CES-2
External IDs	OMIM: 605278; MGI: 3648740; HomoloGene: 128645; GeneCards: CES2; OMA:CES2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 66,934,444 bp[1] End 66,945,096 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D3 Start 105,727,485 bp[2] End 105,747,810 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of ileum mucosa of colon mucosa of sigmoid colon duodenum mucosa of transverse colon mucosa of pharynx rectum right lobe of liver kidney tubule Top expressed in proximal tubule human kidney right kidney duodenum jejunum liver colon testicle islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methylumbelliferyl-acetate deacetylase activity hydrolase activity carboxylic ester hydrolase activity methyl indole-3-acetate esterase activity Cellular component endoplasmic reticulum lumen endoplasmic reticulum extracellular space Biological process xenobiotic metabolic process catabolic process prostaglandin metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8824 436059 Ensembl ENSG00000172831 ENSMUSG00000091813 UniProt O00748 F6Z9B9 RefSeq (mRNA) NM_003869 NM_198061 NM_001365405 NM_001365406 NM_001365407 NM_001365408 NM_001272045 RefSeq (protein) NP_003860 NP_932327 NP_001352334 NP_001352335 NP_001352336 NP_001352337 NP_001258974 Location (UCSC) Chr 16: 66.93 – 66.95 Mb Chr 8: 105.73 – 105.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood–brain barrier system. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[7]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|alt=Irinotecan Pathway edit]]

Irinotecan Pathway edit

1. The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP229".