Alpha/beta hydrolase superfamily

The alpha/beta hydrolase superfamily is a superfamily of hydrolytic enzymes of widely differing phylogenetic origin and catalytic function that share a common fold.^[1] The core of each enzyme is an alpha/beta-sheet (rather than a barrel), containing 8 beta strands connected by 6 alpha helices.^[1][2] The enzymes are believed to have diverged from a common ancestor, retaining little obvious sequence similarity, but preserving the arrangement of the catalytic residues. All have a catalytic triad, the elements of which are borne on loops, which are the best-conserved structural features of the fold.

A bacterial lipase, one of this family members
Identifiers
Symbol	Abhydrolase_1
Pfam	PF00561
Pfam clan	CL0028
ECOD	7579.1.1
InterPro	IPR029058
SCOP2	1ede / SCOPe / SUPFAM
OPM superfamily	127
OPM protein	1qge
CDD	cl21494
Membranome	300
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The alpha/beta hydrolase fold includes proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases.^[3]

Database

The ESTHER database provides a large collection of information about this superfamily of proteins.^[4]

Subfamilies

• 3-oxoadipate enol-lactonase InterPro: IPR012790

Human proteins containing this domain

ABHD10; ABHD11; ABHD12; ABHD12B; ABHD13; ABHD2; ABHD3; ABHD4; ABHD5; ABHD6; ABHD7; ABHD8; ABHD9; BAT5; BPHL; C20orf135; EPHX1; EPHX2; FAM108B1; LIPA; LIPF; LIPJ; LIPK; LIPM; LIPN; LYPLAL1; MEST; MGLL; PPME1; SERHL; SERHL2; SPG21; CES1; CES2; C4orf29

See also

• Ecdysteroid-phosphate phosphatase - structure of a steroid phosphate phosphotase
• Serine hydrolase - an enzyme family that is composed largely of proteins with alpha-beta hydrolase folds

External links

• The ESTHER database