Centrin 2

Centrin-2 is a protein that in humans is encoded by the CETN2 gene.^[5][6][7] It belongs to the centrin family of proteins.

CETN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M39, 1ZMZ, 2A4J, 2GGM, 2K2I, 2OBH
Identifiers
Aliases	CETN2, CALT, CEN2, centrin 2
External IDs	OMIM: 300006; MGI: 1347085; HomoloGene: 55798; GeneCards: CETN2; OMA:CETN2 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 152,826,994 bp[1] End 152,830,757 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A7.3|X 37.29 cM Start 71,957,138 bp[2] End 71,962,017 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell right uterine tube mucosa of paranasal sinus caput epididymis germinal epithelium olfactory zone of nasal mucosa corpus epididymis epithelium of nasopharynx optic nerve tail of epididymis Top expressed in Epithelium of choroid plexus vestibular sensory epithelium atrioventricular valve endocardial cushion epithelium of lens median eminence condyle iris fossa retinal pigment epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heterotrimeric G-protein binding metal ion binding calcium ion binding G-protein beta/gamma-subunit complex binding microtubule binding protein binding Cellular component photoreceptor connecting cilium centriole cytoplasm nucleoplasm ciliary basal body cytosol nucleus XPC complex centrosome intracellular anatomical structure cilium cytoskeleton microtubule organizing center nuclear pore nuclear basket transcription export complex 2 nuclear envelope nuclear pore Biological process nucleotide-excision repair, DNA damage recognition cell cycle spermatogenesis cell division G2/M transition of mitotic cell cycle regulation of cytokinesis centriole replication cellular response to DNA damage stimulus global genome nucleotide-excision repair nucleotide-excision repair, preincision complex assembly DNA repair nucleotide-excision repair ciliary basal body-plasma membrane docking mitotic cell cycle regulation of G2/M transition of mitotic cell cycle mitotic cytokinesis regulation of centrosome duplication calcium-mediated signaling microtubule cytoskeleton organization nucleotide-excision repair, DNA duplex unwinding protein transport mRNA transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1069 26370 Ensembl ENSG00000147400 ENSMUSG00000031347 UniProt P41208 Q9R1K9 RefSeq (mRNA) NM_004344 NM_019405 RefSeq (protein) NP_004335 NP_062278 Location (UCSC) Chr X: 152.83 – 152.83 Mb Chr X: 71.96 – 71.96 Mb PubMed search [3] [4]
Wikidata
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Centrin-2 belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that centrin-2 plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome.^[7]

Interactions

CETN2 has been shown to interact with XPC^[8] and SFI1.^[9]