SFI1

Sfi1 homolog, spindle assembly associated (yeast) is a protein that in humans is encoded by the SFI1 gene. ^[5] It localizes to the centriole, and its S. pombe ortholog has been shown to be involved in spindle pole body duplication.^[6] SFI1 forms a complex with centrin 2.^[7]

SFI1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K2I
Identifiers
Aliases	SFI1, PISD, PPP1R139, hSfi1p, SFI1 centrin binding protein
External IDs	OMIM: 612765; MGI: 1926137; HomoloGene: 12707; GeneCards: SFI1; OMA:SFI1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 31,488,688 bp[1] End 31,618,588 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 3,081,850 bp[2] End 3,143,463 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right uterine tube granulocyte left testis anterior pituitary right testis sural nerve spleen right lobe of thyroid gland left lobe of thyroid gland Top expressed in bronchus trachea lobar bronchus spermatocyte superior frontal gyrus mesothelium of visceral serous pericardium primary visual cortex yolk sac Rostral migratory stream right ventricle More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatase binding protein binding Cellular component cytoplasm centriole cytosol centrosome cytoskeleton Biological process negative regulation of phosphatase activity G2/M transition of mitotic cell cycle ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9814 78887 Ensembl ENSG00000198089 ENSMUSG00000023764 UniProt A8K8P3 Q3UZY0 RefSeq (mRNA) NM_001007467 NM_001258325 NM_001258326 NM_001258327 NM_014775 NM_030207 NM_001363222 NM_001363223 NM_001363224 RefSeq (protein) NP_001007468 NP_001245254 NP_001245255 NP_001245256 NP_055590 NP_084483 NP_001350151 NP_001350152 NP_001350153 Location (UCSC) Chr 22: 31.49 – 31.62 Mb Chr 11: 3.08 – 3.14 Mb PubMed search [3] [4]
Wikidata
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