CHD5

Chromodomain-helicase-DNA-binding protein 5 is an enzyme that in humans is encoded by the CHD5 gene.^[5][6][7] It is a part of the CHD subfamily of ATP-dependent chromatin remodeling complexes.

CHD5
Identifiers
Aliases	CHD5, CHD-5, chromodomain helicase DNA binding protein 5, PMNDS
External IDs	OMIM: 610771; MGI: 3036258; HomoloGene: 56712; GeneCards: CHD5; OMA:CHD5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.31 Start 6,101,787 bp[1] End 6,180,321 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 152,423,108 bp[2] End 152,474,651 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm right frontal lobe cingulate gyrus anterior cingulate cortex Brodmann area 10 Brodmann area 9 pituitary gland left testis right testis primary visual cortex Top expressed in subiculum central gray substance of midbrain dorsal tegmental nucleus cingulate gyrus visual cortex habenula lateral hypothalamus primary visual cortex medial vestibular nucleus paraventricular nucleus of hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding helicase activity metal ion binding H3K27me3 modified histone binding hydrolase activity ATP binding Cellular component NuRD complex membrane heterochromatin nucleus nucleoplasm cytosol nuclear speck Biological process cell differentiation regulation of transcription, DNA-templated histone H3-K27 trimethylation positive regulation of signal transduction by p53 class mediator transcription, DNA-templated nervous system development spermatogenesis histone H4 acetylation cerebral cortex neuron differentiation negative regulation of cell population proliferation chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26038 269610 Ensembl ENSG00000116254 ENSMUSG00000005045 UniProt Q8TDI0 A2A8L1 RefSeq (mRNA) NM_015557 NM_001081376 NM_029216 NM_001369243 RefSeq (protein) NP_056372 NP_001074845 NP_083492 NP_001356172 Location (UCSC) Chr 1: 6.1 – 6.18 Mb Chr 4: 152.42 – 152.47 Mb PubMed search [3] [4]
Wikidata
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