CHFR

E3 ubiquitin-protein ligase CHFR is an enzyme that in humans is encoded by the CHFR gene.^[5][6][7]

CHFR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LGP, 1LGQ, 2XOC, 2XOY, 2XOZ, 2XP0
Identifiers
Aliases	CHFR, RNF116, RNF196, checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase, checkpoint with forkhead and ring finger domains
External IDs	OMIM: 605209; MGI: 2444898; HomoloGene: 10078; GeneCards: CHFR; OMA:CHFR - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.33 Start 132,822,187 bp[1] End 132,956,304 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 110,283,708 bp[2] End 110,319,838 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte skin of hip sural nerve blood right testis left testis gastric mucosa upper lobe of left lung spleen Top expressed in spermatocyte trigeminal ganglion medullary collecting duct endocardial cushion atrioventricular valve gastrula blood neural layer of retina thymus pineal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding ubiquitin protein ligase activity metal ion binding ubiquitin-protein transferase activity transferase activity Cellular component PML body nucleus Biological process mitotic cell cycle checkpoint signaling cell division mitotic cell cycle cell cycle protein polyubiquitination modification-dependent protein catabolic process positive regulation of protein ubiquitination protein destabilization positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55743 231600 Ensembl ENSG00000072609 ENSMUSG00000014668 UniProt Q96EP1 Q810L3 RefSeq (mRNA) NM_018223 NM_001161344 NM_001161345 NM_001161346 NM_001161347 NM_001289577 NM_001289578 NM_001289579 NM_001289580 NM_172717 RefSeq (protein) NP_001154816 NP_001154817 NP_001154818 NP_001154819 NP_060693 NP_001276506 NP_001276507 NP_001276508 NP_001276509 NP_766305 Location (UCSC) Chr 12: 132.82 – 132.96 Mb Chr 5: 110.28 – 110.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CHFR is recruited to sites of DNA damage and participates in the DNA damage response. CHFR has an important role in the survival of male premeiotic germ cells.^[8] About 30% of male CHFR knockout mice are infertile.^[8] In these knockout mice spermatogenesis onset is delayed and apoptosis in premeiotic germ cells is significantly increased. When these mice are 3 months old there is a complete loss of germ cells in their testes.