CHMP4B

Charged multivesicular body protein 4b is a protein that in humans is encoded by the CHMP4B gene.^[5][6]

CHMP4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3C3Q, 3UM3, 4ABM
Identifiers
Aliases	CHMP4B, C20orf178, CHMP4A, CTPP3, CTRCT31, SNF7, SNF7-2, Shax1, VPS32B, Vps32-2, dJ553F4.4, charged multivesicular body protein 4B
External IDs	OMIM: 610897; MGI: 1922858; HomoloGene: 57102; GeneCards: CHMP4B; OMA:CHMP4B - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.22 Start 33,811,348 bp[1] End 33,854,366 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 154,493,625 bp[2] End 154,536,705 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum skin of arm tibialis anterior muscle nasal epithelium mucosa of transverse colon cartilage tissue cardiac muscle tissue of right atrium muscle layer of sigmoid colon gastric mucosa tibial arteries Top expressed in vestibular membrane of cochlear duct Ileal epithelium Epithelium of choroid plexus transitional epithelium of urinary bladder conjunctival fornix substantia nigra facial motor nucleus anterior horn of spinal cord iris motor neuron More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity protein binding identical protein binding cadherin binding Cellular component cytoplasm ESCRT III complex cytosol endosome membrane late endosome membrane cytoplasmic side of plasma membrane membrane coat extracellular exosome vesicle midbody nuclear envelope nucleus Biological process negative regulation of autophagosome assembly regulation of centrosome duplication viral life cycle nucleus organization maintenance of lens transparency multivesicular body assembly negative regulation of cell death regulation of mitotic spindle assembly autophagy endosomal transport posttranslational protein targeting to endoplasmic reticulum membrane ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway protein transport septum digestion after cytokinesis mitotic metaphase plate congression protein homooligomerization vacuolar transport negative regulation of neuron death nuclear membrane reassembly exit from mitosis mitotic cytokinesis regulation of autophagy membrane fission macroautophagy transport viral budding via host ESCRT complex midbody abscission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 128866 75608 Ensembl ENSG00000101421 ENSMUSG00000038467 UniProt Q9H444 Q9D8B3 RefSeq (mRNA) NM_176812 NM_029362 RefSeq (protein) NP_789782 NP_083638 Location (UCSC) Chr 20: 33.81 – 33.85 Mb Chr 2: 154.49 – 154.54 Mb PubMed search [3] [4]
Wikidata
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