CHMP5

Charged multivesicular body protein 5 is a protein that in humans is encoded by the CHMP5 gene.^[4][5][6]

CHMP5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LXM, 3ULY, 3UM0, 3UM1, 3UM2, 4TXR
Identifiers
Aliases	CHMP5, C9orf83, HSPC177, PNAS-2, SNF7DC2, Vps60, CGI-34, charged multivesicular body protein 5
External IDs	OMIM: 610900; MGI: 1924209; HomoloGene: 5757; GeneCards: CHMP5; OMA:CHMP5 - orthologs
Gene location (Mouse) Chr. Chromosome 4 (mouse)[1] Band 4|4 A5 Start 40,948,407 bp[1] End 40,965,303 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium palpebral conjunctiva amniotic fluid visceral pleura sperm parietal pleura bronchial epithelial cell endothelial cell jejunal mucosa glomerulus Top expressed in transitional epithelium of urinary bladder right lung lobe vestibular membrane of cochlear duct pineal gland superior cervical ganglion facial motor nucleus medial ganglionic eminence conjunctival fornix anterior horn of spinal cord gastric mucosa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cadherin binding Cellular component cytoplasm cytosol endosome membrane endosome membrane extracellular exosome nucleus Biological process regulation of centrosome duplication viral life cycle nucleus organization multivesicular body sorting pathway endosome to lysosome transport multivesicular body assembly regulation of mitotic spindle assembly endosomal transport protein transport septum digestion after cytokinesis mitotic metaphase plate congression regulation of receptor recycling lysosome organization vacuolar transport ESCRT III complex disassembly transport midbody abscission cellular response to lipopolysaccharide cellular response to muramyl dipeptide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51510 76959 Ensembl n/a ENSMUSG00000028419 UniProt Q9NZZ3 Q9D7S9 RefSeq (mRNA) NM_016410 NM_001195536 NM_029814 RefSeq (protein) NP_001182465 NP_057494 NP_084090 Location (UCSC) n/a Chr 4: 40.95 – 40.97 Mb PubMed search [2] [3]
Wikidata
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Function

CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.^[6][7]